Numerous authors have reported that 5HT activity influences ill-advised action that appears to be emotion-based. Low levels of 5HTare associated with greater rates of ill-considered behaviors that often involve risk, together with greater levels of negative affect, irritability, and positive affect. This relationship has been demonstrated in both correlational and experimental designs (Cools, Blackwell, Menzies, Cox, & Robbins, 2005; Depue & Collins, 1999; Frankle et al., 2005; Krakowski, 2003; Morgan, Impallomeni, Pirona, & Rogers, 2006; Spoont, 1992; Winstanley, Dalley, Theobald, & Robbins, 2004; Winstanley, Eagle, & Robbins, 2006; Winstanley, Theobald, Dalley, Glennon, & Robbins, 2004; Zald & Depue, 2001).
