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Chunk #37 — Discussion

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Initial evidence that OPRM1 genotype moderates ventral and dorsal striatum functional connectivity during alcohol cues.
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cues. These findings suggest that inhibition of reward and/or habit-driven inputs from the striatum by the prefrontal control circuitry may be unstable among G-allele carriers. Importantly, the G-allele could show similar instability in fronto-striatal connectivity to other cues with incentive salience. Moreover, these results suggest the possibility that strengthening self-control in this group may result in more stable frontal control. Future research elucidating the specificity of this effect seems warranted.