We have made several major modifications to the most recent version of PANTHER. One of the main developments is collaboration with the GO Consortium, in which PANTHER trees are being annotated with GO terms as part of the GO Reference Genome project (5). For PANTHER version 7, all previous associations of PANTHER subfamilies with function terms have been updated to GO terms. Ongoing annotation within the Reference Genome Project includes a complete evidence trail for inferred annotations all the way to the experimental results (literature articles) and evolutionary events upon which the inferences are based. Other important developments include improvements to the phylogenetic trees, inference of inter-species orthologs, inclusion of more genomes and support for several alternate database identifier types.
