In addition to SNPs in the alcohol metabolizing genes, linkage and candidate gene studies have identified the GABRA2, OPRM1, DRD2 and ANNK1 genes, as candidate genes associated with AUD phenotypes (Bühler et al. 2015). However, we did not find robust signals for any of them (Supplementary Table 8), suggesting that previous studies may have overestimated the effects of these genes, or that these genes are associated with AUD but not AUDIT.
