associated SNP explains less than 10% of the genetic variation contributed by the locus. Furthermore, we found that compared to this average, very common associated SNPs explained a smaller proportion of the total variance than less common variants, implying that the variance explained by the causal variants would have to be very high for such very common alleles to have been detected given the power of typical GWAS to date. As noted by Dickson et al., as sample sizes increase the power to detect variants including synthetic associations increases, but in all cases we would expect to see the distribution of RAF skewed towards less common variants.
