In summary, the minor allele of the rs2948694 in the GHSR gene was associated with increased AUDIT scores and smoking possibly reflecting an association with alcohol use disorder and nicotine dependence, respectively. These disorders share common reward mechanisms, involving the mesolimbic dopamine system. The current study suggests that the ghrelin signaling system may be a common denominator and thus a possible target in the development of new treatment strategies for addictive behaviors and disorders.
