Given the above findings demonstrating MSUT2 involvement in determining susceptibility to pathological tau, combined with its role as a nuclear speckle-localized RNA-binding protein, we have begun to explore the role of RNA-binding protein-mediated pathological consequences of tauopathy in AD. In this study, we investigated another nuclear speckle protein, SRRM2, which is a core nuclear speckle scaffold protein required for the formation of nuclear speckles. Recent studies indicate SRRM2 abnormality in AD cellular and animal models [7, 22]. Guided by findings from molecular genetic investigations in model systems, the current study examines the impact of pathological tau on SRRM2 protein in the brains of AD patients and mouse models of tauopathy.
