Chunk #16 — MATERIALS AND METHODS — Cross-population heterogeneity analysis

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The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

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Heterogeneity of odds ratio between EAs and AAs was tested by adding the interaction term β4Gs to Equation 1 [24]. This test is of interest for SNPs that are associated with disease in at least one population. If the interaction term is significant (e.g. p ≤ 0.05, unadjusted for multiple tests), we conclude the genetic effect is different in the two population samples.