dietary preferences [114]. These associations, if causative, may be due to the effects of CNVs on gene dosing, or due to their possible disruption or alteration of transcription factor binding sites, micro-RNAs, or local chromatin architecture. Additionally, several authors have commented on the importance of identifying areas of CNV for proper genotyping of a SNP in the context of a GWAS [115]. As the technology and theory surrounding CNVs continue to improve, and as higher-density, more reliable maps of the frequencies of CNVs in various populations become available, CNVs may take an increasingly prominent role alongside SNPs as targets of a GWAS.
