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Chunk #27 — Results

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Three mutually informative ways to understand the genetic relationships among behavioral disinhibition, alcohol use, drug use, nicotine use/dependence, and their co-occurrence: twin biometry, GCTA, and genome-wide scoring.
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Table 3 reports cross-validated correlations between genome-wide scores generated on one phenotype and correlated with a different phenotype. Note that for some phenotypes (e.g., nicotine use with drug use) the off-diagonal value is greater than the diagonal. We expect this is due to sampling error. Correlations among the drugs are of smaller, but similar, magnitude, ranging from 0.03 to 0.07, suggesting small but detectable pleiotropic SNP effects in this sample.