In summary, this study identified a subset of genes that show differential ASE between subjects with and without AUD; the differences might preexist and affect the risk for AUD or might result from alcohol-induced neurological damage. Within those genes, we identified SNPs that affect gene expression levels in neuronal cells, and are likely to affect expression in the brain, by performing PASSPORT-seq. We believe similar assays should be routinely implemented to screen genetic variants identified by GWAS to identify those that affect gene regulation.
