changes in the importance of positive and negative reinforcement in influencing drinking as a function of AD. To our knowledge, this is the first study to examine within- individual changes in the role of positive and negative reinforcement in relation to alcohol consumption in the absence versus presence of AD. In addition, COGA is a high-risk sample where participants were recruited from families with a history of AD. This resulted in a higher prevalence of alcohol consumption and AD in the sample compared to the general population, as seen in Table 1, allowing us to more reliably estimate parameters to test our hypotheses about the associations between positive and negative reinforcement and alcohol use outcomes.
