as the imbalance between these two neural phenotypes increased (Supplementary Figure 2). In contrast, those individuals in whom both VS activity and amygdala reactivity was either low (<1SD below the mean) or high (>1 SD above the mean) did not show any increase in problem drinking as a function of stress (b estimates< 0.240, p values>0.46). This three-way interaction was independent of gender, age, race/ethnicity, and CTQ scores (b=−0.366, p=0.022), and was not further moderated by any of these factors (all p values>0.60). Furthermore, the three-way interaction remained at trend-levels, with significant simple slopes, when non-drinkers (i.e., individuals with AUDIT scores=0; n=111) were removed from the analysis (without covariates: b=−0.302, p=0.069; with covariates: b=−0.301, p=0.060; Supplementary Figure 3).
