AA/AG individuals) rates of anhedonia (66.1%) were attenuated in those in the top-quartile for abuse exposure. Unlike MOAFTS, there was no evidence for an additive increase in buffering with increasing copies of the A allele. We also examined whether the continuously distributed measure of abuse was associated with anhedonia in GG versus AA/AG individuals. Unlike MOAFTS, the continuous abuse measure was associated with anhedonia in both GG [O.R. 1.65, 95% C.I. 1.44–1.89] and AA/AG [O.R. 1.31, 95% C.I. 1.13–1.51] individuals.
