(114)). Interestingly, at 10 days into abstinence there is a lack of impairment in cognitive flexibility while at 6 weeks into abstinence there were severe impairments in working memory. Furthermore, investigation of anxiety-like behavior, 6 weeks into abstinence, demonstrated a lack of emotional behavioral deficit in abstinent animals (114). Taken together, it is evident that the paradigm of ethanol experience and the type of behavioral investigation are critical when determining alterations in PFC-dependent functions during abstinence, and that some PFC-dependent behaviors are less sensitive to the neurobiological alterations in the PFC in abstinent animals compared with others.
