meta-analysis of prospective population-based cohort studies reported an association with the 12p13 region, thought to be with the NINJ2 gene, although this result was not replicated in a larger case-control sample.12, 13 Recently, the Wellcome Trust Case Control Consortium 2 (WTCCC2) GWAS in ischaemic stroke reported a novel association on chromosome 7p21 within the HDAC9 gene, although it was associated only with large-vessel ischaemic stroke.14
