To validate our matching strategy, we compared the mean value of each of these 24 annotations (for example, proportion of coding SNPs) between non-EUR GWS SNPs and each of the 1,000 random sets of SNPs, using a Fisher’s exact test. For each of the 24 annotations, both the mean and median P value were greater than 0.6 and the proportion of P values < 5% was less than 1%, suggesting no significant differences in the distribution of these 24 annotations between non-EUR GWS SNPs and matched SNPs.
