The Collaborative study on the Genetics of Alcoholism (COGA) (Reich et al., 1998, Edenberg, 2002) is a multi-center collaboration study aimed at identifying genes/variants that affect the risk of AD and related phenotypes. AD probands and their family members were recruited from inpatient and outpatient AD treatment facilities in seven sites; community comparison families were recruited from a variety of sources in the same areas. This study was approved by institutional review boards from all sites and every participant provided informed consent or assent. The Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) and the child version of the SSAGA (Bucholz et al., 1994, Hesselbrock et al., 1999) were used for participants age 18 or over and younger than 18, respectively. COGA samples were genotyped on four genome wide genotyping arrays; genotyping data processing and QC were reported previously (Lai et al., 2019a, Lai et al., 2019b). GWAS of 11 phenotypes in the COGA African American (AA) and European American (EA) samples, as well as meta-analyses of them have been published (Lai et al., 2019a, Lai et al., 2019b, Wetherill
