The UCSC Genes track, which includes protein-coding genes and non-coding RNA genes from RefSeq, GenBank, CCDS (12), Rfam (13) and the tRNA Genes track (14), was updated on both the GRCh37/hg19 human and GRCm38/mm10 mouse assemblies. The human UCSC Genes set increased by 2038 transcripts to a total of 82 960 transcripts, 92% of which did not change between versions. The number of genes, defined as clusters of transcripts with overlapping exons on the same strand, increased by 621 genes to 31 848. In the mouse UCSC Genes set, the number of transcripts grew by 3702 transcripts to 59 121, with 88% remaining the same between versions. The number of genes increased by 2566 genes to 31 227. For more information on the latest methods used to generate the UCSC Genes data, refer to the description pages that accompany the tracks. We also updated the GENCODE Genes (15) track on the latest human assembly to version 17.