[1.72, 3.73], p < .001). However, this effect was only present in G allele homozygotes (bE = 3.68, 95% CI [2.56, 4.81], p < .001); there was no association between CSA and cannabis dependence symptoms in heterozygotes (bE = -0.69, 95% CI [-2.75, 1.38], p = .515), and a negative relationship between CSA and cannabis dependence symptoms in A allele homozygotes (bE = -5.06, 95% CI [-9.30, -0.81], p = .020). Post-hoc Johnson-Neyman tests revealed that the association between genotype and cannabis dependence symptoms was significant at mean-centered log-transformed CSA values of 0.11 and above, corresponding to the endorsement of 1.69 or more forms of childhood sexual abuse. There was no main effect of rs604300 genotype on cannabis dependence symptoms (bG = -0.14, 95% CI [-0.37, 0.08], p = .218), nor was there evidence that genotype was associated with CSA (bG = 0.002, 95% CI [-0.01, 0.01], p = .745).
