There exists limited data on the clinical management of patients with MBL. The great majority of individuals with MBL (approximately 85%) are currently identified as part of the clinical evaluation of an abnormal blood count, most commonly lymphocytosis. These individuals with clinical MBL should undergo a complete evaluation by a hematologist/oncologist that includes a detailed family history (given the association between CLL and MBL), a review for B type symptoms, and a complete physical examination with comprehensive lymph node examination.