Adaptor 6A), and FUT2 (Fucosyltransferase 2). A novel rare ADH1B variant, rs75967634 (p = 1.07 × 10−9, with a minor allele frequency of 0.003), which causes a substitution of histidine for arginine, is in the same codon as rs2066702 (a well-known variant associated with AUD in African populations [3, 8], but not polymorphic in European populations).This association is independent of rs1229984 in ADH1B and rs13125415 (a tag SNP of rs1612735 in MVP phase1 [3]) in ADH1C. The identification of rs75967634 demonstrates the present study’s greater power to detect risk variants in this region, beyond the frequently reported ADH1B*rs1229984.
