0.95 based on a quadratic model). Thus, as an alternative, we performed 1,000 permutations of disease status for the final cohort analyzed for co-expression (278 control and 254 schizophrenia samples), followed by generation of gene co-expression networks and estimation of network preservation statistics. In the permuted sets, we again observed large differences of the network statistics with module size. Therefore, we estimated module size-dependent distributions of null statistics, based on the permuted network statistics for various ranges of binned module sizes: 30–60, 61–125, 125–250, 251–500, 501–1500, and 1501–3000.
