the cell type composition of these brain regions as well as their function. In particular, the cerebellum is known to have a very high concentration of neurons50, and thus cerebellar enrichments could indicate either that the cerebellum is a region that is important in disease etiology, or that neurons are an important cell type. While many pairs of phenotypes had high estimated enrichment correlations in this analysis, migraine tended to have low enrichment correlations with other phenotypes (Figure S8); for example, the estimated enrichment correlation between migraine and schizophrenia was 0.06 (s.e.=0.30) while the estimated enrichment correlation between bipolar disorder and schizophrenia was 0.96 (s.e.=0.05).
