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Chunk #26 — ACUTE EFFECTS OF ALCOHOL ON THE BRAIN IN SOCIAL DRINKERS — Acute effects of alcohol on ERPs

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Understanding alcohol use disorders with neuroelectrophysiology.
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A frontal negativity in the N2 range [variously named as ERN (Error related negativity), FERN, FMN (Fronto-Medial Negativity), ORN (Outcome related negativity)] has been identified as the ERP correlate of the feedback response (Nieuwenhuis et al., 2004; Hajcak et al., 2006). Moderate alcohol has been shown to increase the detrimental effects of incongruent flankers of a visual target in a response inhibition task (Bartholow et al., 2005), along with increased ERN and decreased P3 amplitudes, suggesting a restructuring of self-monitoring processes postalcohol use. To answer the question if alcohol causes a reduction in the efficiency of control processes in general, a study using the flanker task revealed impairments in both interference control and error detection (Ridderinkhof et al., 2002). The investigators found that the frontocentral ERN was attenuated significantly by alcohol consumption while N2 amplitude was not, indicating that alcohol in moderate doses produced a significant deterioration in detection of erroneous responses (ERN). Another study suggested that later stages of outcome processing were affected by alcohol, as indicated by reduced P300 to loss feedback (Euser et al., 2011). Motor preparation