note that since we primarily evaluated summary statistics from the discovery and replication cohorts, additional work with raw genotype data is needed to determine whether the AD-associated MAPT effect varies based on APOE ε4 carrier status. Another concern is the potential ‘contamination’ of PD samples with other tauopathies (such as PSP and CBD) strongly associated with MAPT. Using neuropathologically confirmed PD cases, a recent study 46 found a significant association between rs393152 and idiopathic PD indicating that our current findings are unlikely due to contamination with unrecognized cases of PSP or CBD.
