combinations of self-report and clinical cutoffs on those self-report measures accounting for the other half.7 Other studies 8,10 investigated a broader trait definition of depression, which provided a larger sample size; a greater number of novel loci were discovered, with the potential caveat of less specificity to depression.11 We had available in MVP several potential case definitions, and chose to focus on the definition that provided the highest heritability: the EHR derived International Classification of Diseases (ICD) codes for MDD..
