Expression of NR2C2, ZFYVE20, CAPN7 and SH3BP5 transcripts was significantly correlated with expression of many alcohol and nicotine dependence-related genes, including those in the dopaminergic[Batel et al., 2008; Stapleton et al., 2007], serotoninergic[Hasegawa et al., 2002], cholinergic [Lou et al., 2006; Saccone et al., 2009], GABAergic [Chang et al., 2002], glutamatergic [Edenberg et al., 2010], histaminergic [Oroszi et al., 2005], endocannabinoid [Zuo et al., 2007], opoid [Zhang et al., 2008], alcohol metabolic[Luo et al., 2006; Uhl et al., 2008] and neuropeptide[Wetherill et al., 2008] systems. These findings suggested that SH3BP5-NR2C2 might also be implicated in alcohol dependence via the classical neurotransmission systems or metabolic pathways.
