Variation in ADH1B is the most frequently identified molecular genetic risk factor for alcohol dependence. The variant 369Cys allele is associated with reduced risk of alcohol dependence (Gelernter et al. 2014). More than half of the DNA samples in the present study (N = 1291) were genotyped on the Illumina HumanOmniExpress Beadchip containing 980,000 SNPs. Including rs2066702. The rest (N = 955) were genotyped on the Illlumina HumanCoreExome BeadChip containing approximately 550,000 SNPs, which did not include rs2066702. In these samples the SNP was imputed based on 1000 Genomes phase 3 data data (http://www.1000genomes.org/about) using IMPUTE 2 (https://mathgen.stats.ox.ac.uk/impute/impute_v2.html).
