Chunk #8 — METHODS — SIMULATIONS — Genotype data

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A comparison of approaches to account for uncertainty in analysis of imputed genotypes.

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For each of 100 one-megabase (1-Mb) regions, we simulated 10,000 chromosomes from a coalescent model that mimics LD in real data, accounts for variation in local recombination rates, and models population history consistent with the HapMap CEU and YRI analysis panels [Schaffner et al., 2005].