Transcriptional control of “gene batteries” has been shown to coordinate effector gene expression and cellular properties (Hobert et al., 2010). Our study substantiates the role PCG1α transcription program in coordinating multiple physiological and metabolic properties in PVBCs (Figure 7J). Together with results of highly congruent expression of functional gene ensembles in other PCPs (e.g. NO-cGMP signaling pathway in LPCs), the cumulative evidence precludes piece meal, coincidental mechanisms of co-expression and suggests transcriptional programs that maintain cell phenotypes and identity.
