et al., 1998; Saccone et al., 2000; Wilhelmsen et al., 2003) to more fully test for susceptibility loci contributing to alcohol misuse. We then conducted follow-up analyses for identified linkage peaks by conducting linkage analysis for each of the 12 alcohol dependence symptoms assessed by the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) (Bucholz et al., 1994) to determine which symptoms were responsible for the linkage signal. Finally, exploratory linkage analyses were conducted for symptom clusters assessing withdrawal, severe drinking, and medical/mental health problems.
