While overlapping a priori gene sets between modules suggests shared functionality between these gene co-expression networks, we also identified a priori gene sets that were unique to each of the significant mRNA modules. Specifically, 51 a priori gene sets were unique among five of the six modules, with no unique gene sets enriched in M grey60. Of these, 24 gene sets were uniquely enriched in Mturquoise, a neuron-associated module, with genes involved in mRNA processing and degradation, DNA repair, protein modification, and glucose and carbohydrate metabolism. In M yellow, also a neuron-associated module, genes involved in neurotransmitter binding/transmission and opioid signaling, long-term potentiation, calcium signaling and translation regulation pathways were enriched among 9 gene sets. Of the glial cell-associated modules, M green exhibited enrichment with 12 gene sets related to immune function and signaling, apoptosis, and actin cytoskeleton regulation. M pink and M salmon were enriched for gene sets with genes involved in glycosaminoglycan metabolism, Notch signaling, and lysosomal activity, respectively. The full list of unique enriched gene sets is given in S5 Table.
