Human and mouse ARID-containing proteins can be classified into seven subfamilies: ARID1, ARID2, ARID3, ARID4, ARID5, JARID1 and JARID2. Within each designated subfamily, the degree of identity within the ARID regions is very high, ranging from 70 to 83% (Figure 1). In contrast, identity between ARID regions across subfamilies is <30%. Members within subfamilies generally also show clear relationships outside the ARID, as shown in Figure 2. These subclassifications are the basis for the current nomenclature of the ARID family, which has recently been accepted by the HUGO Gene Nomenclature Committee (HGNC) and the Mouse Genomic Nomenclature Committee (MGNC).
