Using the pretest/posttest design, Figure 1 shows the change in rates of substance use from before the pandemic (September 2019-January 2020) to the first survey during the pandemic (May-June 2020) in a subsample of youth (n = 1,079). The past-30-day prevalence of alcohol use decreased from 1.9% to 0.7% (p = .03). The past-30-day prevalence increased for use of nicotine (0% to 1.5%; p = .005) and misuse of prescription drugs (0% to 0.7%; p = .05). Changes in the rates of use of any substance, cannabis, or inhalants were not statistically significant.