Collectively, the development of differentiation protocols for serotonergic and GABAergic neuronal populations will pave the way for examining the role of these populations in the pathogenesis of depression and anxiety, and may eventually open the door for cell-based therapies in human. In vitro models could also be used to pre-select the most effective therapy for patients with MDD and anxiety disorders, as a step towards the application of precision medicine in psychiatry.
