to modulate circuits that have not yet been demonstrated to be intermediate phenotypes (e.g. genes modulating prefrontal cortex coupling during working memory tasks or genes modulating hippocampus activity during episodic memory), and not all reported neuroimaging intermediate phenotypes have been systematically investigated with risk genes, despite clear evidence of their being enriched in healthy relatives (e.g., cognitive control). Connecting these two different lines of investigation could greatly contribute to the field's progress in understanding the complex pathophysiology of psychiatric disorders.
