Although one could assess the accuracy of EEE via simulations, it would be difficult to conduct simulations over a sufficiently broad range of circumstances to evaluate whether EEE has the flexibility to adapt to almost any testing situation. Instead, following the conceptual lead of Micceri [15], we rely on multiple studies of specialized statistical genetic techniques published in the literature as test cases and ask empirically, if an investigator used EEE to estimate their power or required sample size by beginning with the readily available published literature as a base from which to project, how accurate would they be? An advantage of this approach coupled with the large number of statistical genetic simulation studies published is that it allows statistical methodology to be practiced as much an empirical as a theoretical science.
