Significant cis-acting eSNPs in this study were examined for possible replication of a small number of eQTL that have been linked to inflammatory bowel disease (IBD) in the past. Additionally, 163 genome-wide associated IBD SNPs established using the ImmunoChip platform34 were evaluated in a subset of subjects for which ImmunoChip data were available. These SNPs were selected for a targeted, hypothesis-driven eQTL analysis performed both in cis and in trans fashion.