was found in the interval between 168 and 170 Mbp, and only 16 were found between 173 and 178 Mbp. The 170- to 173-Mbp interval is a relatively gene-poor region, containing only 20 known or predicted genes. These are Pbx1, Nuf2, Rgs5, Rgs4, 1700084C01Rik, Ddr2, Hsd17b7, Uhmk1, Uap1, Sh2d1b1, 1700015E13Rik, Nos1ap, Olmfml2b, Atf6, Dusp12, Fcrla, Fcrlb, Fcgr3, Fcgr2b, and Fcgr4. Two of these genes (Nos1ap {nitric oxide synthase [neuronal] adaptor protein} and Atf6 {activating transcription factor 6}) can be linked to ethanol response (Spanagel et al. 2002; Chen et al. 2008). Both genes have been reported to have coding non-synonymous SNPs (http://phenome.jax.org/pub-cgi/phenome/) with the129:B6=D2=CBy haplotype structure. The LP and C strains were sequenced to confirm that these SNPs also had the LP:B6=D2=C haplotype structure.
