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Chunk #25 — Results — Association of Candidate Phenotypes with rs2066702 in African Americans

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AUDIT-C and ICD codes as phenotypes for harmful alcohol use: association with ADH1B polymorphisms in two US populations.
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These findings indicate that the combination of age-adjusted mean AUDIT-C score and AUD diagnostic codes yields more information among AAs. Comparing AAs with an age-adjusted mean AUDIT-C of 8 to those with a score of 0, the adjusted odds of having the ADH1B minor allele was 0.59 (95% CI 0.47, 0.75) (Table 2b). Having an AUD independently reduced the odds by 0.86 (95% CI 0.83, 0.90). Having both an AUDIT-C score of 8+ with an AUD diagnosis compared to an AUDIT-C of 0 and no AUD diagnosis would reduce the aOR of having the rs2066702 minor allele to 0.51 (data not otherwise shown).