In summary, we have provided a detailed examination of the genetic and environmental contributions to genetic ancestry transcriptional changes in the brain. We leveraged genetic diversity within an admixed population to limit environmental confounders, resulting in converging evidence of the immune response in genetic ancestry-associated transcriptional changes in the brain. The research we have provided substantively furthers our understanding of the contribution of genetic ancestry in the brain, opening new avenues to the development of ancestry-aware therapeutics and paving the way for equitable, personalized medicine.
