The ZNF804A variants examined in this study confer risk of more than one category of disease. Rs1344706[T] is associated with both schizophrenia and bipolar disorder, and the CNVs identified here suggest a connection with anxiety as well, although we do not find evidence for the association of rs1344706[T] with anxiety (data not shown). The functional connectivity alterations identified in the brains of rs1344706[T] carriers5 provide a possible mechanism for the link between ZNF804A variants and a diversity of disorders. Thus, examination of brain functional connectivity in ZNF804A CNV carriers would be of interest.
