Results of single marker analyses are shown in Table 1. In the data from ZNF804A, rs1344706 (associated in the original report in discovery and combined replication samples) is also associated in the ICCSS (one-tailed p=0.0113). The same allele (A) is increased in frequency in cases compared to controls as in the original study. In total, we observe nominal evidence of association between schizophrenia and 4 of the 11 SNPs passing QC criteria. The T allele of rs7597593 yields substantially more significant evidence of association (two-tailed p=0.0013), but this SNP lacks the evidence of possible functional significance observed for rs1344706 (see below). The single marker results from rs7597593 (p=0.0013) remain significant after Bonferroni correction for 10 tests. Allele and genotype counts are shown in Table S1.
