gene expression co-localisation (sentinel variant and top expression variant r2≥0.9, Table 2). We found that the 68 high-priority genes were overrepresented (FDR≤5%) among a number of gene ontology terms including SH3 domain binding, GTPase binding, actin binding and fibroblast migration (Supplementary Table 16). Alternative approaches to pathway analyses, which instead use all genome-wide association results, supported previous reports of enrichment of histone and systemic lupus erythematosus pathways14–16 and additional autoimmune and inflammatory pathways (Supplementary Table 17). Tests for tissue-specific enrichment of lung function signals overlapping histone marks identified enrichment in fetal lung, fetal heart and fibroblasts (H3K4me1), and stomach smooth muscle (H3K4me1 and H3K4me3) (Supplementary Table 18).
