Subsequent to the interim release of genotypes (May 2015) for approximately 150,000 UK Biobank participants improvements were made to the genotype calling algorithm35 and quality control procedures. We therefore expect to observe some changes in the genotype calls and missing data profile of samples included in both the interim data release and this final data release. Discordance among non-missing markers is very low (mean 6.7 × 10−5; Supplementary Fig. 1); and for each sample there are 24,500 genotype calls (on average) that were missing in the interim data, but which have non-missing calls in this release. This is much smaller in the reverse direction, with 500 calls, on average, missing in this release but not missing in the interim data, so there is an average net gain of 24,000 genotype calls per sample.
