Chunk #66 — SPECIFIC MECHANISMS OF TUMOR SUPPRESSION AND THERAPEUTIC TARGETING — Synergy between TopoII and BAF complexes

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Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.

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Because BAF subunit mutations prevent TopoII from contacting DNA, these studies predict that cancers with BAF subunit mutations should be resistant to TopoII inhibitors. This has not been shown to date, but could be helpful in guiding the use of these highly toxic inhibitors.