In depression, anhedonia, including disruptions in normal anticipatory response and in goal‐directed behavior, is considered a core symptom27 that has been employed to assess depression susceptibility.16 At the preclinical level, PR responding has been extensively used to dissect the effects of depressive‐like state in motivation toward natural23 and drug‐related rewards.20 In drug addiction, persistent preoccupation and heightened motivation to acquire the drug of abuse are central to disease diagnosis.1 Consequently, PR schedules have been employed to assess the incentive value of drugs of abuse both in humans and in rodents28, 29 and are considered essential in prediction of addiction proneness at the preclinical level.30
