Onset of first symptom of alcohol dependence was associated with an increased risk of becoming sexually active at age 16 or younger, HR = 1.7, p<.001. In addition, onset of first symptom of conduct disorder was linked with a greater risk of sexual debut at 16 or younger, HR = 1.8, p<.001. Greater risk of sexual debut at age 16 or younger was also associated with membership in families afflicted with at least one case of alcohol dependence disorder. Specifically, participants whose biological parents were not diagnosed with alcohol dependence but who had a biological alcohol dependent relative (aunt, uncle, or grandparent) were at greater risk of becoming sexually active at age 16 or younger than comparison participants, HR = 1.8, p<.001. Having one or more biological parents with alcohol dependence was associated with an increased risk of early sexual debut using as comparison, participants with no biological alcohol dependent parents as baseline, HR = 2.0, p<.001 (mother only is alcohol dependent), HR = 2.4, p<.001 (father only is alcohol dependent), HR = 2.6, p<.001 (both parents are alcohol dependent).
