top 30 genes. Among the top 30 genes was Brain-Derived Neurotrophic Factor (BDNF, P = 0.0003), a gene also implicated, though not genome-wide significant, in Terracciano et al. (2010), as was the BDNF anti-sense RNA gene (P = 0.0001).Table 2Top SNPs from the meta-analysis of GWA results in 29 discovery cohorts for extraversion, and their replication in the GS:SFHS cohort, in the Genetics of Personality ConsortiumSNPChr_BPAllelesClosest geneDiscovery resultsReplication resultsEffectSE P-valueEffectSE P-valuers20244882_217662968A/G LOC101928250 −0.03030.00592.939 x 10−7 0.02850.01640.08244rs27121622_217661788T/C LOC101928250 −0.03000.00593.872 x 10−7 0.02780.01640.08947rs79718212_10900487A/G<NA>−0.02770.00566.673 x 10−7 −0.01350.01530.37721rs801030614_37150160A/G SLC25A21 0.06290.01288.730 x 10−7 0.01800.03140.56650rs11729286019_2227621A/C DOT1L 0.05530.01139.191 x 10−7 −0.03500.02390.14368Table 3Top genes from the meta-analysis of GWA results in 29 discovery cohorts for Extraversion in the Genetics of Personality ConsortiumGeneFull gene namePathways P-value LOC101928162 [Long non-coding RNA]Unknown0.00000287 LOC729506 [Long non-coding RNA]Unknown0.00000893 PLEKHJ1 Pleckstrin Homology Domain Containing, Family J Member 1Phospholipid binding, circadian clock functioning0.0000132 POU2F3 POU Class 2 Homeobox 3Influenza A0.0000179 CRTAC1 Cartilage Acidic Protein 1Unknown0.0000297
